Rabbit ZFP36L1 Polyclonal Antibody | anti-ZFP36L1 antibody

ZFP36L1 Rabbit Polyclonal

Cat. Num. AAA7605857

• Gene Names: ZFP36L1; BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ZFP36L1; Polyclonal Antibody; ZFP36L1 Rabbit Polyclonal; anti-ZFP36L1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 407

• Applicable Applications for anti-ZFP36L1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Zinc finger protein 36, C3H type-like 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovary tissue slide using MBS7605857 (ZFP36L1 Antibody) at dilution of 1:50)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7605857 (ZFP36L1 Antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 347659013
• NCBI GeneID: 677
• NCBI Accession #: NP_001231630.1
• NCBI GenBank Nucleotide #: NM_001244701.1
• Molecular Weight: 36,314 Da
• NCBI Official Full Name: zinc finger protein 36, C3H1 type-like 1 isoform 2
• NCBI Official Synonym Full Names: ZFP36 ring finger protein-like 1
• NCBI Official Symbol: ZFP36L1
• NCBI Official Synonym Symbols: BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B
• NCBI Protein Information: zinc finger protein 36, C3H1 type-like 1
• UniProt Protein Name: Zinc finger protein 36, C3H1 type-like 1
• Protein Family: mRNA decay activator protein
• UniProt Gene Name: ZFP36L1
• UniProt Synonym Gene Names: BERG36; BRF1; ERF1; RNF162B; TIS11B; ERF-1
• UniProt Entry Name: TISB_HUMAN

NCBI Description

This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Description

BRF1: a zinc finger protein that plays an important role in the assembly of the RNA polymerase III initiation factor TFIIIB. Regulates mRNA levels by targeting transcripts containing AREs (AU-rich elements) into the decay pathway. Phosphorylation by Akt apparently generates 14-3-3 binding sites and inhibits BRF1 from promoting mRNA activity.Contains 2 C3H1-type zinc fingers.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 14q22-q24

Cellular Component: cytosol; nucleus

Molecular Function: AU-rich element binding; DNA binding; metal ion binding; mRNA binding; protein binding; transcription factor activity

Biological Process: apoptosis; cell proliferation; heart development; mRNA catabolic process, deadenylation-dependent decay; multicellular organism growth; neural tube development; regulation of mRNA stability; regulation of transcription, DNA-dependent; regulation of translation; T cell differentiation in the thymus; vasculogenesis