Rabbit Spartin, SPG20 Polyclonal Antibody | anti-SPG20 antibody

Spartin, SPG20 Rabbit Polyclonal

Cat. Num. AAA7604388

• Gene Names: SPG20; SPARTIN; TAHCCP1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: Spartin; SPG20; Polyclonal Antibody; SPG20 Rabbit Polyclonal; anti-SPG20 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 666

• Applicable Applications for anti-SPG20 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)
• Immunogen: Spastic paraplegia 20 (Troyer syndrome)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gliomas using MBS7604388 (Spartin, SPG20 antibody) at dilution of 1:100)

Western Blot (WB)

(NIH/3T3 cells were subjected to SDS PAGE followed by western blot with MBS7604388 (Spartin, SPG20 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 214830109
• NCBI GeneID: 23111
• NCBI Accession #: NP_001135767.1
• NCBI GenBank Nucleotide #: NM_001142295.1
• Molecular Weight: 72,833 Da
• NCBI Official Full Name: spartin
• NCBI Official Synonym Full Names: spastic paraplegia 20 (Troyer syndrome)
• NCBI Official Symbol: SPG20
• NCBI Official Synonym Symbols: SPARTIN; TAHCCP1
• NCBI Protein Information: spartin
• UniProt Protein Name: Spartin
• Protein Family: Spartin
• UniProt Gene Name: SPG20
• UniProt Synonym Gene Names: KIAA0610; TAHCCP1
• UniProt Entry Name: SPG20_HUMAN

NCBI Description

This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]

Uniprot Description

SPG20: May be implicated in endosomal trafficking, or microtubule dynamics, or both. Defects in SPG20 are the cause of spastic paraplegia autosomal recessive type 20 (SPG20); also known as Troyer syndrome (TRS). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG20 is characterized by dysarthria, distal amyotrophy, mild developmental delay and short stature.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: cytoplasm; lipid particle; midbody; mitochondrial outer membrane; plasma membrane; synapse

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: abscission; cell division; negative regulation of BMP signaling pathway; negative regulation of collateral sprouting in the absence of injury; neuromuscular process; regulation of mitochondrial membrane potential

Disease: Spastic Paraplegia 20, Autosomal Recessive