Rabbit MMP1 Polyclonal Antibody | anti-MMP1 antibody

MMP1 Rabbit Polyclonal

Cat. Num. AAA7601466

• Gene Names: MMP1; CLG; CLGN
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence, Immunoprecipitation, Flow Cytometry, Functional Assay, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: MMP1; Polyclonal Antibody; MMP1 Rabbit Polyclonal; anti-MMP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 232

• Applicable Applications for anti-MMP1 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytomwtry (FC/FACS), Immunohistochemistry (IHC)
• Immunogen: Matrix metallopeptidase 1 (interstitial collagenase)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using MBS7601466 (MMP1 Antibody) at dilution of 1:200)

Western Blot (WB)

(A549 cells were subjected to SDS PAGE followed by western blot with MBS7601466 (MMP1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 15341877
• NCBI GeneID: 4312
• Molecular Weight: 54,007 Da
• NCBI Official Full Name: MMP1 protein, partial
• NCBI Official Synonym Full Names: matrix metallopeptidase 1
• NCBI Official Symbol: MMP1
• NCBI Official Synonym Symbols: CLG; CLGN
• NCBI Protein Information: interstitial collagenase
• UniProt Protein Name: Interstitial collagenase
• Protein Family: Interstitial collagenase
• UniProt Gene Name: MMP1
• UniProt Synonym Gene Names: CLG; MMP-1
• UniProt Entry Name: MMP1_HUMAN

NCBI Description

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Description

MMP1: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Belongs to the peptidase M10A family.

Protein type: Protease; Motility/polarity/chemotaxis; Secreted; EC 3.4.24.7; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: extracellular region; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; endopeptidase activity; metalloendopeptidase activity; serine-type endopeptidase activity; zinc ion binding

Biological Process: cellular protein metabolic process; collagen catabolic process; extracellular matrix disassembly; leukocyte migration; positive regulation of protein oligomerization; proteolysis; viral reproduction

Disease: Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Pulmonary Disease, Chronic Obstructive