Rabbit MBD5 Polyclonal Antibody | anti-MBD5 antibody

MBD5 Rabbit Polyclonal

Cat. Num. AAA7601270

• Gene Names: MBD5; MRD1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: MBD5; Polyclonal Antibody; MBD5 Rabbit Polyclonal; anti-MBD5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 110

• Applicable Applications for anti-MBD5 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Methyl-CpG binding domain protein 5
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse heart tissue were subjected to SDS PAGE followed by western blot with MBS7601270 (MBD5 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 119850921
• NCBI GeneID: 55777
• Molecular Weight: 89,418 Da
• NCBI Official Full Name: MBD5 protein, partial
• NCBI Official Synonym Full Names: methyl-CpG binding domain protein 5
• NCBI Official Symbol: MBD5
• NCBI Official Synonym Symbols: MRD1
• NCBI Protein Information: methyl-CpG-binding domain protein 5
• UniProt Protein Name: Methyl-CpG-binding domain protein 5
• Protein Family: Methyl-CpG-binding domain protein
• UniProt Gene Name: MBD5
• UniProt Synonym Gene Names: KIAA1461
• UniProt Entry Name: MBD5_HUMAN

NCBI Description

This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. [provided by RefSeq, Mar 2010]

Uniprot Description

MBD5: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro). Defects in MBD5 are the cause of mental retardation autosomal dominant type 1 (MRD1). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 2q23.1

Cellular Component: chromocenter; nucleus

Molecular Function: chromatin binding; DNA binding

Biological Process: glucose homeostasis; nervous system development; positive regulation of defense response to virus by host; regulation of multicellular organism growth

Disease: Mental Retardation, Autosomal Dominant 1