Rabbit anti-Human HBG1 Polyclonal Antibody | anti-HBG1 antibody
HBG1-Specific Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
NCBI and Uniprot Product Information
NCBI Description
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
Uniprot Description
HBG1: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. Belongs to the globin family.
Protein type: Carrier
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytosol; hemoglobin complex
Molecular Function: heme binding; iron ion binding; oxygen binding; oxygen transporter activity
Biological Process: blood coagulation; oxygen transport
Disease: Fetal Hemoglobin Quantitative Trait Locus 1