Human A/G specific adenine DNA glycosylase (MUTYH) ELISA Kit | MUTYH elisa kit
Human A/G specific adenine DNA glycosylase (MUTYH) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
MUTYH: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Tumor suppressor; DNA repair, damage; Mitochondrial; EC 3.2.2.-
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: nucleoplasm; mitochondrion; nucleus
Molecular Function: protein binding; 4 iron, 4 sulfur cluster binding; metal ion binding; hydrolase activity, acting on glycosyl bonds; MutLalpha complex binding; MutLbeta complex binding; MutSbeta complex binding; MutSalpha complex binding
Biological Process: mismatch repair; base-excision repair, AP site formation; depurination; base-excision repair; DNA repair
Disease: Gastric Cancer; Pilomatrixoma; Familial Adenomatous Polyposis, 2
Research Articles on MUTYH
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Product Notes
The Human MUTYH mutyh (Catalog #AAA7246568) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7246568 ELISA Kit recognizes Human MUTYH. It is sometimes possible for the material contained within the vial of "A/G specific adenine DNA glycosylase (MUTYH), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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