Human Regulator of G protein signaling 9 binding protein (RGS9BP) ELISA Kit | RGS9BP elisa kit

Human Regulator of G protein signaling 9 binding protein (RGS9BP) ELISA Kit

Cat. Num. AAA7245394

• Gene Names: RGS9BP; R9AP; RGS9; PERRS
• Reactivity: Human
• Synonyms: Regulator of G protein signaling 9 binding protein (RGS9BP); Human Regulator of G protein signaling 9 binding protein (RGS9BP) ELISA Kit; RGS9BP elisa kit

• Reactivity: Human

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Assay Type: Competitive
• Detection Range: 250-5000pg/mL
• Sensitivity: 1.0pg/mL
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for RGS9BP elisa kit

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 115496700
• NCBI GeneID: 388531
• NCBI Accession #: NP_997274.2
• NCBI GenBank Nucleotide #: NM_207391.2
• Molecular Weight: 25,148 Da
• NCBI Official Full Name: regulator of G-protein signaling 9-binding protein
• NCBI Official Synonym Full Names: regulator of G protein signaling 9 binding protein
• NCBI Official Symbol: RGS9BP
• NCBI Official Synonym Symbols: R9AP; RGS9; PERRS
• NCBI Protein Information: regulator of G-protein signaling 9-binding protein; RGS9 anchor protein; RGS9-anchoring protein
• UniProt Protein Name: Regulator of G-protein signaling 9-binding protein
• Protein Family: Regulator of G-protein signaling 9-binding protein
• UniProt Gene Name: RGS9BP
• UniProt Synonym Gene Names: R9AP
• UniProt Entry Name: R9BP_HUMAN

NCBI Description

The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia. [provided by RefSeq, Mar 2010]

Uniprot Description

RGS9BP: Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation. Defects in RGS9BP are a cause of prolonged electroretinal response suppression (PERRS); also known as bradyopsia. PERRS is characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones. Belongs to the RGS7BP/RGS9BP family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.11

Cellular Component: integral to membrane

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; detection of light stimulus involved in visual perception; negative regulation of signal transduction

Disease: Prolonged Electroretinal Response Suppression