Mouse Cyclin-dependent kinase 5 activator 1 (CDK5R1) ELISA Kit | CDK5R1 elisa kit
Mouse Cyclin-dependent kinase 5 activator 1 (CDK5R1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
Uniprot Description
CDK5R1: activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cyclin-dependent protein kinase 5 activator complex; intracellular membrane-bound organelle; contractile fiber; postsynaptic density; dendrite; dendritic spine; cytosol; nucleoplasm; growth cone; cell soma; membrane; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; neuromuscular junction; nucleus
Molecular Function: protein serine/threonine kinase activator activity; protein binding; ephrin receptor binding; cyclin-dependent protein kinase activity; cadherin binding; cyclin-dependent protein kinase 5 activator activity; kinase activity; calcium ion binding; protein kinase binding; protein kinase activity
Biological Process: axon guidance; superior olivary nucleus maturation; regulation of neuron differentiation; rhythmic process; neuron migration; negative regulation of axon extension; neuron differentiation; positive regulation of neuron apoptosis; ephrin receptor signaling pathway; cerebellum development; neuron adhesion; layer formation in the cerebral cortex; neurite development; serine phosphorylation of STAT3 protein; acetylcholine receptor signaling, muscarinic pathway; hippocampus development; axonal fasciculation; peptidyl-threonine phosphorylation; cell proliferation; peptidyl-serine phosphorylation; embryonic development; ionotropic glutamate receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; regulation of cyclin-dependent protein kinase activity; brain development; negative regulation of transcription, DNA-dependent
Research Articles on CDK5R1
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Product Notes
The Mouse CDK5R1 cdk5r1 (Catalog #AAA7245150) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7245150 ELISA Kit recognizes Mouse CDK5R1. It is sometimes possible for the material contained within the vial of "Cyclin-dependent kinase 5 activator 1 (CDK5R1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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