Guinea Pig NF-kappa-B inhibitor-like protein 1 (NFKBIL1) ELISA Kit | NFKBIL1 elisa kit
Guinea pig NF-kappa-B inhibitor-like protein 1 (NFKBIL1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Uniprot Description
NFKBIL1: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. Defects in NFKBIL1 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: nucleoplasm; intermediate filament cytoskeleton; nucleus; cytosol
Molecular Function: protein binding
Biological Process: negative regulation of lipopolysaccharide-mediated signaling pathway; I-kappaB kinase/NF-kappaB cascade; cytoplasmic sequestering of transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production
Disease: Rheumatoid Arthritis
Research Articles on NFKBIL1
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Product Notes
The Guinea Pig NFKBIL1 nfkbil1 (Catalog #AAA7244240) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7244240 ELISA Kit recognizes Guinea Pig NFKBIL1. It is sometimes possible for the material contained within the vial of "NF-kappa-B inhibitor-like protein 1 (NFKBIL1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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