Human F box only protein 5 (FBXO5) ELISA Kit | FBXO5 elisa kit

Human F box only protein 5 (FBXO5) ELISA Kit

Cat. Num. AAA7242485

• Gene Names: FBXO5; EMI1; FBX5; Fbxo31
• Reactivity: Human
• Synonyms: F box only protein 5 (FBXO5); Human F box only protein 5 (FBXO5) ELISA Kit; FBXO5 elisa kit

• Reactivity: Human

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Assay Type: Competitive
• Detection Range: 0.5-10ng/mL
• Sensitivity: 0.1ng/mL
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for FBXO5 elisa kit

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 215982802
• NCBI GeneID: 26271
• NCBI Accession #: NP_001135994.1
• NCBI GenBank Nucleotide #: NM_001142522.1
• Molecular Weight: 45,353 Da
• NCBI Official Full Name: F-box only protein 5 isoform b
• NCBI Official Synonym Full Names: F-box protein 5
• NCBI Official Symbol: FBXO5
• NCBI Official Synonym Symbols: EMI1; FBX5; Fbxo31
• NCBI Protein Information: F-box only protein 5; F-box protein Fbx5; early mitotic inhibitor 1
• UniProt Protein Name: F-box only protein 5
• Protein Family: F-box only protein
• UniProt Gene Name: FBXO5
• UniProt Synonym Gene Names: EMI1; FBX5
• UniProt Entry Name: FBX5_HUMAN

NCBI Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

Uniprot Description

FBX5: a member of the SCFs class of F-box proteins. F-box proteins constitute one of the subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. FBX5 is an early mitotic inhibitor-1 (Emi1) that interacts with Cdc20 and inhibits the anaphase promoting complex (APC/C). APC/C is a ubiquitin ligase that targets mitotic regulatory proteins for degradation. FBX5 accumulates in the S phase and is rapidly degraded in prometaphase.

Chromosomal Location of Human Ortholog: 6q25.2

Cellular Component: nucleoplasm; cytoplasm; spindle; cytosol; nucleus

Molecular Function: protein binding; metal ion binding; protein kinase binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; vesicle organization and biogenesis; regulation of mitotic cell cycle; oocyte maturation; G1/S-specific transcription in mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of meiosis; mitotic cell cycle; mitotic metaphase/anaphase transition; spindle assembly involved in female meiosis I; microtubule polymerization; G1/S transition of mitotic cell cycle