Guinea Pig Cytochrome c oxidase assembly protein COX11, mitochondrial (COX11) ELISA Kit | COX11 elisa kit
Guinea pig Cytochrome c oxidase assembly protein COX11, mitochondrial (COX11) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]
Uniprot Description
COX11: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. Belongs to the COX11/CtaG family.
Protein type: Mitochondrial; Oxidoreductase; Membrane protein, integral; Energy Metabolism - oxidative phosphorylation
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane
Molecular Function: cytochrome-c oxidase activity; copper ion binding; electron carrier activity
Biological Process: negative regulation of glucokinase activity; respiratory chain complex IV assembly; respiratory gaseous exchange
Research Articles on COX11
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Product Notes
The Guinea Pig COX11 cox11 (Catalog #AAA7237309) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7237309 ELISA Kit recognizes Guinea Pig COX11. It is sometimes possible for the material contained within the vial of "Cytochrome c oxidase assembly protein COX11, mitochondrial (COX11), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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