Rat ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1) ELISA Kit | SUPV3L1 elisa kit
Rat ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SUPV3L1: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. Belongs to the helicase family.
Protein type: Mitochondrial; EC 3.6.4.13; DNA-binding; RNA-binding; Helicase
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: mitochondrion; mitochondrial matrix; nucleus
Molecular Function: DNA helicase activity; protein binding; protein homodimerization activity; DNA binding; RNA binding; double-stranded RNA binding; helicase activity; ATP-dependent RNA helicase activity; ATP binding
Biological Process: RNA catabolic process; positive regulation of cell growth; DNA duplex unwinding; negative regulation of apoptosis; DNA recombination