Goat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (ASAP2) ELISA Kit | ASAP2 elisa kit

Goat Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (ASAP2) ELISA Kit

Cat. Num. AAA7229277

• Gene Names: ASAP2; PAP; PAG3; AMAP2; DDEF2; SHAG1; CENTB3; Pap-alpha
• Reactivity: Goat
• Synonyms: Arf-GAP with SH3 domain; ANK repeat and PH domain-containing protein 2 (ASAP2); Goat Arf-GAP with SH3 domain; ANK repeat and PH domain-containing protein 2 (ASAP2) ELISA Kit; ASAP2 elisa kit

• Reactivity: Goat

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for ASAP2 elisa kit

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4502249
• NCBI GeneID: 8853
• NCBI Accession #: NP_003878.1
• NCBI GenBank Nucleotide #: NM_003887.2
• Molecular Weight: 106,982 Da
• NCBI Official Full Name: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform a
• NCBI Official Synonym Full Names: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
• NCBI Official Symbol: ASAP2
• NCBI Official Synonym Symbols: PAP; PAG3; AMAP2; DDEF2; SHAG1; CENTB3; Pap-alpha
• NCBI Protein Information: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; centaurin, beta 3; PYK2 C terminus-associated protein; pyk2 C-terminus-associated protein; development and differentiation enhancing factor 2; development and differentiation-enhancing factor 2; paxillin-associated protein with ARF GAP activity 3
• UniProt Protein Name: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
• Protein Family: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
• UniProt Gene Name: ASAP2
• UniProt Synonym Gene Names: DDEF2; KIAA0400; PAG3; PAP
• UniProt Entry Name: ASAP2_HUMAN

NCBI Description

This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Uniprot Description

DDEF2: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, ARF; GAPs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p25|2p24

Cellular Component: plasma membrane

Molecular Function: protein binding; zinc ion binding; enzyme activator activity

Biological Process: positive regulation of catalytic activity; positive regulation of GTPase activity