Guinea Pig Chloride channel protein ClC-Ka (CLCNKA) ELISA Kit | CLCNKA elisa kit
Guinea pig Chloride channel protein ClC-Ka (CLCNKA) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CLCNKA: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Defects in CLCNKA are a cause of Bartter syndrome type 4B (BS4B). A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness. Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: metal ion binding; voltage-gated chloride channel activity
Biological Process: transport; excretion; transmembrane transport
Disease: Bartter Syndrome, Type 4b
Research Articles on CLCNKA
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Product Notes
The Guinea Pig CLCNKA clcnka (Catalog #AAA7228932) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7228932 ELISA Kit recognizes Guinea Pig CLCNKA. It is sometimes possible for the material contained within the vial of "Chloride channel protein ClC-Ka (CLCNKA), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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