Rabbit Mitochondria-eating protein (SPATA18) ELISA Kit | SPATA18 elisa kit
Rabbit Mitochondria-eating protein (SPATA18) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SPATA18: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Belongs to the MIEAP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: mitochondrial outer membrane; intracellular membrane-bound organelle; cytoplasm
Molecular Function: protein binding
Biological Process: response to DNA damage stimulus
Research Articles on SPATA18
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Product Notes
The Rabbit SPATA18 spata18 (Catalog #AAA7221063) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7221063 ELISA Kit recognizes Rabbit SPATA18. It is sometimes possible for the material contained within the vial of "Mitochondria-eating protein (SPATA18), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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