Human CMP N acetylneuraminate beta 1, 4 galactoside Alpha 2, 3 sialyltransferase ELISA Kit | ST3GAL3 elisa kit
Human CMP N acetylneuraminate beta 1, 4 galactoside Alpha 2, 3 sialyltransferase ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with autosomal recessive nonsymdromic mental retardation-12 (MRT12). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Uniprot Description
ST3GAL3: Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- or NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3- GalNAc. Defects in ST3GAL3 are the cause of mental retardation autosomal recessive type 12 (MRT12). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the glycosyltransferase 29 family. 26 isoforms of the human protein are produced by alternative splicing.
Protein type: Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Transferase; EC 2.4.99.6; Membrane protein, integral; Glycan Metabolism - keratan sulfate biosynthesis
Chromosomal Location of Human Ortholog: 1pter-p32.3
Disease: Mental Retardation, Autosomal Recessive 12
Research Articles on ST3GAL3
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Product Notes
The Human ST3GAL3 st3gal3 (Catalog #AAA7216164) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7216164 ELISA Kit recognizes Human ST3GAL3. It is sometimes possible for the material contained within the vial of "CMP N acetylneuraminate beta 1, 4 galactoside Alpha 2, 3 sialyltransferase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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