Mouse Atrial natriuretic peptide receptor 2 (NPR2) ELISA Kit | NPR2 elisa kit
Mouse Atrial natriuretic peptide receptor 2 (NPR2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
Uniprot Description
ANPB: natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. 21 mutations linked to acromesomelic dysplasia (skeletal malformation). 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Guanylyl cyclase; Kinase, protein; EC 4.6.1.2; Receptor, misc.; Lyase; Nucleotide Metabolism - purine; Protein kinase, dual-specificity (receptor); Protein kinase, RGC; Membrane protein, integral; RGC group; RGC family
Chromosomal Location of Human Ortholog: 9p21-p12
Cellular Component: integral to membrane; plasma membrane
Molecular Function: identical protein binding; guanylate cyclase activity; transmembrane receptor activity; hormone binding; GTP binding; natriuretic peptide receptor activity; peptide hormone binding; receptor activity; ATP binding; protein kinase activity
Biological Process: cGMP biosynthetic process; ossification; cell surface receptor linked signal transduction; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; negative regulation of meiotic cell cycle; signal transduction; protein amino acid phosphorylation
Disease: Short Stature With Nonspecific Skeletal Abnormalities; Epiphyseal Chondrodysplasia, Miura Type; Acromesomelic Dysplasia, Maroteaux Type
Research Articles on NPR2
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Product Notes
The Mouse NPR2 npr2 (Catalog #AAA7209901) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7209901 ELISA Kit recognizes Mouse NPR2. It is sometimes possible for the material contained within the vial of "Atrial natriuretic peptide receptor 2 (NPR2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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