Guinea Pig Cingulin-like protein 1 (CGNL1) ELISA Kit | CGNL1 elisa kit
Guinea pig Cingulin-like protein 1 (CGNL1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
CGNL1: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. Defects in CGNL1 are a cause of aromatase excess syndrome (AEXS). A disorder characterized by an estrogen excess due to an increased aromatase activity. A chromosomal aberration inv(15)(q21.2;q21.3) has been found in patients with aromatase excess syndrome. The inversion moves the promoter of the CGNL1 gene into a 5-prime position in relation to the aromatase coding region. Belongs to the cingulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 15q21.3
Cellular Component: tight junction; myosin complex
Molecular Function: motor activity
Biological Process: metabolic process
Research Articles on CGNL1
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Product Notes
The Guinea Pig CGNL1 cgnl1 (Catalog #AAA7209891) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7209891 ELISA Kit recognizes Guinea Pig CGNL1. It is sometimes possible for the material contained within the vial of "Cingulin-like protein 1 (CGNL1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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