Monkey Cyclin-D-binding Myb-like transcription factor 1 (DMTF1) ELISA Kit | DMTF1 elisa kit
Monkey Cyclin-D-binding Myb-like transcription factor 1 (DMTF1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Description
DMTF1: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'. Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. Belongs to the DMTF1 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Tumor suppressor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 7q21
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: DNA binding; chromatin binding; transcription factor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; cell cycle
Research Articles on DMTF1
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Product Notes
The Monkey DMTF1 dmtf1 (Catalog #AAA7206988) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7206988 ELISA Kit recognizes Monkey DMTF1. It is sometimes possible for the material contained within the vial of "Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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