Guinea Pig Coiled-coil domain-containing protein 39 (CCDC39) ELISA Kit | CCDC39 elisa kit
Guinea pig Coiled-coil domain-containing protein 39 (CCDC39) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in the motility of cilia and flagella. The encoded protein is essential for the assembly of dynein regulatory and inner dynein arm complexes, which regulate ciliary beat. Defects in this gene are a cause of primary ciliary dyskinesia type 14 (CILD14). [provided by RefSeq, Jul 2011]
Uniprot Description
CCDC39: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. Defects in CCDC39 are the cause of primary ciliary dyskinesia type 14 (CILD14). A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the CCDC39 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 3q26.33
Cellular Component: cytoskeleton; axoneme
Biological Process: heart looping; lung development
Disease: Ciliary Dyskinesia, Primary, 14
Research Articles on CCDC39
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Product Notes
The Guinea Pig CCDC39 ccdc39 (Catalog #AAA7206755) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7206755 ELISA Kit recognizes Guinea Pig CCDC39. It is sometimes possible for the material contained within the vial of "Coiled-coil domain-containing protein 39 (CCDC39), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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