Chloride intracellular channel protein 5 (CLIC5) Recombinant Protein | CLIC5 recombinant protein

Recombinant Bovine Chloride intracellular channel protein 5 (CLIC5)

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Chloride intracellular channel protein 5 (CLIC5); Recombinant Bovine Chloride intracellular channel protein 5 (CLIC5); Recombinant Chloride intracellular channel protein 5 (CLIC5); Chloride intracellular channel protein 5; Chlorine channel protein p64; CLIC5 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-437
• Sequence: MNDENYSTTIYNRVQTERVYEDSDPAENGGPLYDEVHEDVRREDNLYVNELENQEYDSVAVYPVGRQGRTSASLQPETGEYVLPDEPYSKAQDPHPGEPTADEDISLEELLSPTKDHQSDSEEPQASDPEEPQASDPEEPQGPDPEEPQENGNEMEADLPSPSSFTIQNSRAFSTREISPTSYSADDVSEGNESASASPEINLFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPRLAAKHRESNTAGIDIFVKFSAYIKNTKQQSNAALERGLTKALKKLDDYLNTPLPEEIDADTRGDDEKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDFPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS
• Sequence Length: 437

• Species: Bos taurus (Bovine)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 27805879
• NCBI GeneID: 281696
• NCBI Accession #: NP_776701.1
• NCBI GenBank Nucleotide #: NM_174276.3
• UniProt Accession #: P35526
• Molecular Weight: 48,959 Da
• NCBI Official Full Name: chloride intracellular channel protein 5
• NCBI Official Symbol: CLIC5
• NCBI Protein Information: chloride intracellular channel protein 5; chloride channel protein p64; chlorine channel protein p64
• UniProt Protein Name: Chloride intracellular channel protein 5
• Protein Family: Chloride intracellular channel protein
• UniProt Gene Name: CLIC5
• UniProt Entry Name: CLIC5_BOVIN

Uniprot Description

Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Required for normal formation of stereocilia in the inner ear and normal development of the organ of Corti

By similarity.

Subunit structure: Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, and IQGAP1

By similarity.

Subcellular location: Golgi apparatus

By similarity. Cytoplasm › cytoskeleton › centrosome

By similarity. Membrane; Single-pass membrane protein

By similarity. Cytoplasm

By similarity. Note: Colocalized with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain

By similarity.

Tissue specificity: Expressed in most tissues. Higher levels found in kidney, heart, skeletal muscle, T84 and PANC-1 cells.

Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion

By similarity.

Post-translational modification: Phosphorylated

Probable.

Sequence similarities: Belongs to the chloride channel CLIC family.Contains 1 GST C-terminal domain.