Rabbit ATRIP Polyclonal Antibody | anti-ATRIP antibody

Phospho-ATRIP (Ser68) Antibody

Cat. Num. AAA7132970

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography usin
• Synonyms: ATRIP; Polyclonal Antibody; Phospho-ATRIP (Ser68) Antibody; TREX1; anti-ATRIP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography usin
• Form/Format: Liquid; Supplied at 1.0mg/mL In Phosphate Buffered Saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.

• Applicable Applications for anti-ATRIP antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Peptide sequence around phosphorylation site of Serine 68(L-A-S(p)-Q-A) derived from Human ATRIP.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blot analysis of extracts from 3T3 cells using ATRIP (Phospho-Ser68) Antibody.The lane on the left is treated with the antigen-specific peptide. )

Product Categories/Family for anti-ATRIP antibody

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 402534571
• NCBI GeneID: 84126
• NCBI Accession #: NP_001257951.1
• NCBI GenBank Nucleotide #: NM_001271022.1
• UniProt Accession #: Q8WXE1; Q69YK9; Q8NHQ2; Q8WUG7; Q96CL3; Q9HA30; A8K6A3; A8K714; B2RCE7
• Molecular Weight: 85,838 Da
• NCBI Official Full Name: ATR-interacting protein isoform 3
• NCBI Official Synonym Full Names: ATR interacting protein
• NCBI Official Symbol: ATRIP
• NCBI Protein Information: ATR-interacting protein; ATM and Rad3-related-interacting protein
• UniProt Protein Name: ATR-interacting protein
• Protein Family: ATR-interacting protein
• UniProt Gene Name: ATRIP
• UniProt Synonym Gene Names: AGS1
• UniProt Entry Name: ATRIP_HUMAN

NCBI Description

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Uniprot Description

ATRIP: is required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Heterodimerizes with ATR. The heterodimer binds replication protein A (RPA), a protein complex that subsequently is recruited to single stranded DNA (ssDNA). Its EEXXXDDL motif is required for the interaction with catalytic subunit of DNA-PK and its recruitment to sites of DNA damage. e for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame. Three alternatively spliced human isoforms have been reported.

Protein type: DNA repair, damage; DNA-binding; Cell cycle regulation

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: DNA damage checkpoint; DNA repair; DNA replication