Western Blot (WB)
(Western Blot analysis of SH-SY5Y cells using Nephrocystin-5 Polyclonal Antibody)
Rabbit anti-Human IQCB1 Polyclonal Antibody | anti-IQCB1 antibody
IQCB1 Antibody
IHC: 1:100-1:300
ELISA: 1:40000
Western Blot (WB)
(Western Blot analysis of SH-SY5Y cells using Nephrocystin-5 Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of SH-SY5Y cells using Nephrocystin-5 Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 293 Jurkat cells using Nephrocystin-5 Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 293 Jurkat cells using Nephrocystin-5 Polyclonal Antibody)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Uniprot Description
IQCB1: Involved in ciliogenesis. Defects in IQCB1 are the cause of Senior-Loken syndrome type 5 (SLSN5). SLSN is a renal-retinal disorder, characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 3q13.33|3q21.1
Cellular Component: nucleoplasm; microtubule cytoskeleton; centrosome; intercellular bridge; photoreceptor outer segment; cytosol; photoreceptor connecting cilium
Molecular Function: calmodulin binding; protein binding; enzyme binding
Biological Process: organelle organization and biogenesis; photoreceptor cell maintenance; cilium biogenesis; maintenance of organ identity
Disease: Senior-loken Syndrome 5
Research Articles on IQCB1
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Product Notes
The IQCB1 iqcb1 (Catalog #AAA7122204) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IQCB1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IQCB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:500-1:2000 IHC: 1:100-1:300 ELISA: 1:40000. Researchers should empirically determine the suitability of the IQCB1 iqcb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IQCB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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