Post-GPI attachment to proteins factor 3 (PGAP3) Recombinant Protein | PGAP3 recombinant protein

Recombinant Human Post-GPI attachment to proteins factor 3 (PGAP3), partial

• Gene Names: PGAP3; CAB2; PERLD1; PP1498; hCOS16; AGLA546
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Post-GPI attachment to proteins factor 3 (PGAP3); Recombinant Human Post-GPI attachment to proteins factor 3 (PGAP3); partial; PGAP3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 299

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 619726944
• NCBI GeneID: 93210
• NCBI Accession #: NP_001278655.1
• NCBI GenBank Nucleotide #: NM_001291726.1
• UniProt Accession #: Q96FM1; Q86Z03; Q8NBJ8; B4DGK7
• Molecular Weight: 33,967 Da
• NCBI Official Full Name: post-GPI attachment to proteins factor 3 isoform 2
• NCBI Official Synonym Full Names: post-GPI attachment to proteins 3
• NCBI Official Symbol: PGAP3
• NCBI Official Synonym Symbols: CAB2; PERLD1; PP1498; hCOS16; AGLA546
• NCBI Protein Information: post-GPI attachment to proteins factor 3
• UniProt Protein Name: Post-GPI attachment to proteins factor 3
• Protein Family: Post-GPI attachment to proteins factor
• UniProt Gene Name: PGAP3
• UniProt Synonym Gene Names: CAB2; PERLD1; hCOS16

NCBI Description

This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

Uniprot Description

Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable).