Tripartite motif-containing 13 (Trim13) Recombinant Protein | Trim13 recombinant protein
Recombinant Rat Tripartite motif-containing 13 (Trim13)
NCBI and Uniprot Product Information
Uniprot Description
Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B.
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Product Notes
The Trim13 trim13 (Catalog #AAA7057975) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-407, full length protein. The amino acid sequence is listed below: MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGLLEG NVRNSLWRPS PFKCPTCRKE TSATGVNSLQ VNYSLKGIVE KYNKIKISPK MPVCKEHLGQ PLNIFCVTDM QLICGVCATR GSHTKHVFSS IEDAYTQERD AFEFLFQSFE TWRRGDALSR LDTLETNKRK SLQLLTKDSD KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQTYDPEIN KLNSILQEQR MAFNIAEAFK DVSEPIIFLQ QMQEFREKIK VIKETPLPPS NLPTSPLMKN FDTSQWEDIK LVDVDKLSLP QDTGVLTSRS PWHPCLLLMA VVLLGLLVFF GPTVFLEWSP LEELATWKDC LSSFNSYLTK SADFVEQSVF YWEQMTDGLF VFSERVKNVS LVALNNVAEF VCKYKLL. It is sometimes possible for the material contained within the vial of "Tripartite motif-containing 13 (Trim13), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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