Transmembrane protein 2 (TMEM2) Recombinant Protein | TMEM2 recombinant protein

Recombinant Human Transmembrane protein 2 (TMEM2) , partial

Cat. Num. AAA7057652

• Gene Names: CEMIP2; TMEM2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transmembrane protein 2 (TMEM2); Recombinant Human Transmembrane protein 2 (TMEM2); partial; TMEM2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,320

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 209447096
• NCBI GeneID: 23670
• NCBI Accession #: NP_001129292.1
• NCBI GenBank Nucleotide #: NM_001135820.1
• UniProt Accession #: Q9UHN6; Q5T838; Q5T839; Q5T840; Q5T841; Q8NBP6; Q9P2D5; A6H8W9; B2RTQ6
• Molecular Weight: 18.0 kDa
• NCBI Official Full Name: cell surface hyaluronidase isoform b
• NCBI Official Synonym Full Names: cell migration inducing hyaluronidase 2
• NCBI Official Symbol: CEMIP2
• NCBI Official Synonym Symbols: TMEM2
• NCBI Protein Information: cell surface hyaluronidase; transmembrane protein 2
• UniProt Protein Name: Cell surface hyaluronidase
• Protein Family: Transmembrane protein
• UniProt Gene Name: TMEM2

NCBI Description

This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]

Uniprot Description

Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172).