Rabbit anti-Human CD180 Polyclonal Antibody | anti-CD180 antibody

CD180 Antibody

Cat. Num. AAA7044802

• Gene Names: CD180; LY64; Ly78; RP105
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: CD180; Polyclonal Antibody; CD180 Antibody; CD180 antigen; Lymphocyte antigen 64; Radioprotective 105 kDa protein; LY64; RP105; anti-CD180 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 661

• Applicable Applications for anti-CD180 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Species: Human
• Immunogen: Recombinant human CD180 antigen protein (24-220AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: CD180 antibody at 3.95ug/mlLane 1: A549 whole cell lysateLane 2: A431 whole cell lysateLane 3: HepG-2 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 74 kDaObserved band size: 74 kDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human tonsil tissue MBS7044802 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human spleen tissue MBS7044802 at dilution 1:100)

Related Product Information for anti-CD180 antibody

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 167555127
• NCBI GeneID: 4064
• NCBI Accession #: NP_005573.2
• NCBI GenBank Nucleotide #: NM_005582.2
• UniProt Accession #: Q99467; Q32MM5; B2R7Z7
• Molecular Weight: 74,179 Da
• NCBI Official Full Name: CD180 antigen
• NCBI Official Synonym Full Names: CD180 molecule
• NCBI Official Symbol: CD180
• NCBI Official Synonym Symbols: LY64; Ly78; RP105
• NCBI Protein Information: CD180 antigen
• UniProt Protein Name: CD180 antigen
• Protein Family: CD180 antigen
• UniProt Gene Name: CD180
• UniProt Synonym Gene Names: LY64; RP105
• UniProt Entry Name: CD180_HUMAN

NCBI Description

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

Uniprot Description

CD180: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q12

Cellular Component: integral to plasma membrane

Molecular Function: receptor activity

Biological Process: inflammatory response; positive regulation of lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway