5,6-dihydroxyindole-2-carboxylic acid oxidase Recombinant Protein | Tyrp1 recombinant protein
5,6-dihydroxyindole-2-carboxylic acid oxidase
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
TYRP1: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3); also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Belongs to the tyrosinase family.
Protein type: Membrane protein, integral; Oxidoreductase; Amino Acid Metabolism - tyrosine; EC 1.14.18.-
Cellular Component: endosome membrane; melanosome; melanosome membrane
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: acetoacetic acid metabolic process; melanin biosynthetic process from tyrosine; melanin metabolic process; melanocyte differentiation; melanosome organization and biogenesis; pigmentation; positive regulation of melanin biosynthetic process
Research Articles on Tyrp1
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Product Notes
The Tyrp1 tyrp1 (Catalog #AAA7043531) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 25-537. Full Length of Mature Protein. The amino acid sequence is listed below: QFPRECANIE ALRRGVCCPD LLPSSGPGTD PCGSSSGRGR CVAVIADSRP HSRHYPHDGK DDREAWPLRF FNRTCQCNDN FSGHNCGTCR PGWRGAACNQ KILTVRRNLL DLSPEEKSHF VRALDMAKRT THPQFVIATR RLEDILGPDG NTPQFENISV YNYFVWTHYY SVKKTFLGTG QESFGDVDFS HEGPAFLTWH RYHLLQLERD MQEMLQEPSF SLPYWNFATG KNVCDVCTDD LMGSRSNFDS TLISPNSVFS QWRVVCESLE EYDTLGTLCN STEGGPIRRN PAGNVGRPAV QRLPEPQDVT QCLEVRVFDT PPFYSNSTDS FRNTVEGYSA PTGKYDPAVR SLHNLAHLFL NGTGGQTHLS PNDPIFVLLH TFTDAVFDEW LRRYNADIST FPLENAPIGH NRQYNMVPFW PPVTNTEMFV TAPDNLGYAY EVQWPGQEFT VSEIITIAVV AALLLVAAIF GVASCLIRSR STKNEANQPL LTDHYQRYAE DYEELPNPNH SMV . It is sometimes possible for the material contained within the vial of "5,6-dihydroxyindole-2-carboxylic acid oxidase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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