TGF-beta receptor type-2 Recombinant Protein | TGFBR2 recombinant protein
TGF-beta receptor type-2
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.
Protein type: Kinase, protein; Membrane protein, integral; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Oncoprotein; TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 3p22
Cellular Component: caveola; cytosol; external side of plasma membrane; integral to membrane; lipid raft; plasma membrane; receptor complex
Molecular Function: glycosaminoglycan binding; protein binding; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; apoptosis; blood vessel development; brain development; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; heart development; myeloid dendritic cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; palate development; patterning of blood vessels; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of B cell tolerance induction; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; regulation of cell proliferation; response to drug; transforming growth factor beta receptor signaling pathway; vasculogenesis
Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 6; Esophageal Cancer; Loeys-dietz Syndrome 2
Research Articles on TGFBR2
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Product Notes
The TGFBR2 tgfbr2 (Catalog #AAA7043432) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 23-567. Full-length. The amino acid sequence is listed below: TIPPHVQKSV NNDMIVTDNN GAVKFPQLCK FCDVRFSTCD NQKSCMSNCS ITSICEKPQE VCVAVWRKND ENITLETVCH DPKLPYHDFI LEDAASPKCI MKEKKKPGET FFMCSCSSDE CNDNIIFSEE YNTSNPDLLL VIFQVTGISL LPPLGVAISV IIIFYCYRVN RQQKLSSTWE TGKTRKLMEF SEHCAIILED DRSDISSTCA NNINHNTELL PIELDTLVGK GRFAEVYKAK LKQNTSEQFE TVAVKIFPYE EYASWKTEKD IFSDINLKHE NILQFLTAEE RKTELGKQYW LITAFHAKGN LQEYLTRHVI SWEDLRKLGS SLARGIAHLH SDHTPCGRPK MPIVHRDLKS SNILVKNDLT CCLCDFGLSL RLDPTLSVDD LANSGQVGTA RYMAPEVLES RMNLENVESF KQTDVYSMAL VLWEMTSRCN AVGEVKDYEP PFGSKVREHP CVESMKDNVL RDRGRPEIPS FWLNHQGIQM VCETLTECWD HDPEARLTAQ CVAERFSELE HLDRLSGRSC SEEKIPEDGS LNTTK . It is sometimes possible for the material contained within the vial of "TGF-beta receptor type-2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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