UDP-glucuronosyltransferase 1-1 (Ugt1a1) Recombinant Protein | Ugt1a1 recombinant protein
Recombinant Mouse UDP-glucuronosyltransferase 1-1 (Ugt1a1)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
UGT1A1: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Expressed in liver. Not expressed in skin or kidney. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Lipid Metabolism - androgen and estrogen; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - other enzymes; Carbohydrate Metabolism - ascorbate and aldarate; EC 2.4.1.17; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Carbohydrate Metabolism - pentose and glucuronate interconversions; Xenobiotic Metabolism - drug metabolism - cytochrome P450
Cellular Component: endoplasmic reticulum; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; membrane
Molecular Function: enzyme binding; enzyme inhibitor activity; glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; retinoic acid binding; steroid binding; transferase activity; transferase activity, transferring glycosyl groups; transferase activity, transferring hexosyl groups
Biological Process: flavone metabolic process; flavonoid biosynthetic process; metabolic process; negative regulation of catalytic activity; response to organic substance
Research Articles on Ugt1a1
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Product Notes
The Ugt1a1 ugt1a1 (Catalog #AAA7032806) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 30-535. Full-Length of the Mature Protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Ugt1a1 ugt1a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: GRLLVFPMDG SHWLSMLGVI QQLQQKGHEV VVIAPEASIH IKEGSFYTLR KFPVPFQKEN VTATLVELGR TAFNQDSFLL RVVKIYMKVK RDSSMLLAGC SHLLHNAEFM ASLEESHFDA LLTDPFLPCG SIVAQYLTVP TVYFLNKLPC SLDSEATQCP VPLSYVPKSL SFNSDRMNFL QRVKNVLLAV SENFMCRVVY SPYGSLATEI LQKEVTVQDL LSPASIWLMR SDFVKDYPRP IMPNMVFIGG INCLQKKPLS QEFEAYVNAS GEHGIVVFSL GSMVSEIPEK KAMEIAEALG RIPQTVLWRY TGTRPSNLAK NTILVKWLPQ NDLLGHPKTR AFITHSGSHG IYEGICNGVP MVMMPLFGDQ MDNAKRMETR GAGVTLNVLE MTADDLENAL KTVINNKSYK ENIMRLSSLH KDRPIEPLDL AVFWVEYVMR HKGAPHLRPA AHDLTWYQYH SLDVIGFLLA IVLTVVFIVF KCCAYGCRKC FGGKGRVKKS HKSKTH . It is sometimes possible for the material contained within the vial of "UDP-glucuronosyltransferase 1-1 (Ugt1a1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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