E3 ubiquitin-protein ligase RNF144B (Rnf144b) Recombinant Protein | Rnf144b recombinant protein
Recombinant Mouse E3 ubiquitin-protein ligase RNF144B (Rnf144b)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
RNF144B: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. Belongs to the RBR family. RNF144 subfamily.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase; Ligase
Cellular Component: cytoplasm; integral to membrane; membrane; mitochondrial membrane; mitochondrion; ubiquitin ligase complex
Molecular Function: coenzyme F420-0 gamma-glutamyl ligase activity; coenzyme F420-2 alpha-glutamyl ligase activity; ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; zinc ion binding
Biological Process: apoptosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
Research Articles on Rnf144b
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Product Notes
The Rnf144b rnf144b (Catalog #AAA7028736) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-301aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Rnf144b rnf144b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MDSVDGLQCL TMTAENPPSG DLIPAPLVTC KLCLCEQSLD KMTMLQECQC IFCTPCLKQY MVLSIREGCG SPITCPDMVC LNHGTLQETE IACLVPLDEF QLYQRLKFER EVHMDPLRTW CPVADCQTVC HISAGDPGQP VLVECPSCHL KFCSCCKDAW HEESSCRDSQ SAMPEHGALF GTDADAPIKQ CPVCRIYIER NEGCAQMMCK NCKHTFCWYC LQNLDNDIFL RHYDKGPCRN KLGHSRASVM WNRTQVVGIL VGLGVIALVT SPLLLLASPC IICCVCKSCR GKKKKHDPST T. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase RNF144B (Rnf144b), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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