Rabbit anti-Human ASZ1 Polyclonal Antibody | anti-ASZ1 antibody

ASZ1 Antibody

Cat. Num. AAA7006833

• Gene Names: ASZ1; ALP1; GASZ; Orf3; ANKL1; C7orf7; CT1.19
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%,Protein G purified
• Synonyms: ASZ1; Polyclonal Antibody; ASZ1 Antibody; Ankyrin repeat; SAM and basic leucine zipper domain-containing protein 1; Ankyrin-like protein 1; Germ cell-specific ankyrin; SAM and basic leucine zipper domain-containing protein; anti-ASZ1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 466

• Applicable Applications for anti-ASZ1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: Recombinant human Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-79854 / sc-79852
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis tissue MBS7006833 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovarian cancer MBS7006833 at dilution 1:100)

Western Blot (WB)

(Western BlotPositive WB detected in: Rat brain tissueAll lanes: ASZ1 antibody at 2.7ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 54,53 KDaObserved band size: 54 KDa)

Immunofluorescence (IF)

(Immunofluorescent analysis of HepG2 cells using MBS7006833 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-ASZ1 antibody

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

NCBI and Uniprot Product Information

• NCBI GI #: 685844859
• NCBI GeneID: 136991
• NCBI Accession #: NP_001288750.1
• NCBI GenBank Nucleotide #: NM_001301821.1
• UniProt Accession #: Q8WWH4; A0AV27; A4D0V0; B7ZM20
• Molecular Weight: 52,432 Da
• NCBI Official Full Name: ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 isoform 2
• NCBI Official Synonym Full Names: ankyrin repeat, SAM and basic leucine zipper domain containing 1
• NCBI Official Symbol: ASZ1
• NCBI Official Synonym Symbols: ALP1; GASZ; Orf3; ANKL1; C7orf7; CT1.19
• NCBI Protein Information: ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
• UniProt Protein Name: Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
• Protein Family: Ankyrin repeat, SAM and basic leucine zipper domain-containing protein
• UniProt Gene Name: ASZ1
• UniProt Entry Name: ASZ1_HUMAN

Uniprot Description

ASZ1: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: cytoplasm

Molecular Function: signal transducer activity

Biological Process: cell differentiation; DNA methylation during gametogenesis; gene expression; male meiosis; multicellular organismal development; RNA-mediated gene silencing; signal transduction; spermatogenesis