Western Blot (WB)
(Western blotAll lanes: CYP2E1 antibody at 12ug/mlLane 1:Jurkat whole cell lysateLane 2:mouse liver tissueSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 57kDaObserved band size: 57kDa)
Rabbit anti-Human, mouse CYP2E1 Polyclonal Antibody | anti-CYP2E1 antibody
CYP2E1 Antibody
Western Blot (WB)
(Western blotAll lanes: CYP2E1 antibody at 12ug/mlLane 1:Jurkat whole cell lysateLane 2:mouse liver tissueSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 57kDaObserved band size: 57kDa)
Western Blot (WB)
(Western blotAll lanes: CYP2E1 antibody at 12ug/mlLane 1:Jurkat whole cell lysateLane 2:mouse liver tissueSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 57kDaObserved band size: 57kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human brain tissue using MBS7002461 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human brain tissue using MBS7002461 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
Uniprot Description
CYP2E1: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. Belongs to the cytochrome P450 family.
Protein type: Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 1.14.13.n7; Xenobiotic Metabolism - metabolism by cytochrome P450; Mitochondrial; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: endoplasmic reticulum membrane; Golgi membrane; intrinsic to endoplasmic reticulum membrane; mitochondrion
Molecular Function: arachidonic acid epoxygenase activity; enzyme binding; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; steroid hydroxylase activity
Biological Process: drug metabolic process; epoxygenase P450 pathway; heterocycle metabolic process; monoterpenoid metabolic process; response to drug; response to ethanol; response to organic nitrogen; response to ozone; steroid metabolic process; triacylglycerol metabolic process; xenobiotic metabolic process
Research Articles on CYP2E1
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Product Notes
The CYP2E1 cyp2e1 (Catalog #AAA7002461) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CYP2E1 Antibody reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CYP2E1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Recommended dilution: WB:1:500-2000, IHC:1:20-1:200. Researchers should empirically determine the suitability of the CYP2E1 cyp2e1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYP2E1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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