MIP-1 beta (CCL4) active protein
Human MIP-1 beta (CCL4)
NCBI and Uniprot Product Information
NCBI Description
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein is similar to CCL4 which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals; most individuals have 1-5 copies in the diploid genome, although rare individuals do not contain this gene at all. The human genome reference assembly contains two copies of this gene. This record represents the more centromeric gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B Ref.13 Ref.14 Ref.15
Subunit structure: Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). Ref.15
Subcellular location: Secreted.
Induction: By mitogens.
Post-translational modification: N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
Caution: Was originally (Ref.12) thought to be a ligand for CCR8.
Research Articles on MIP-1 beta (CCL4)
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Product Notes
The MIP-1 beta (CCL4) ccl4 (Catalog #AAA692135) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human MIP-1 beta (CCL4) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKR GKQV CADPSESWVQ EYVYDLELN. It is sometimes possible for the material contained within the vial of "MIP-1 beta (CCL4), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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