Lungkine (CXCL15) Active Protein | CXCL15 active protein
Mouse Lungkine (CXCL15)
Gene Names
Cxcl15; Il8; weche; Scyb15; lungkine
Reactivity
Mouse
Purity
> 98% by SDS-PAGE
Synonyms
Lungkine (CXCL15); Mouse Lungkine (CXCL15); Recombinant Murine Lungkine; CXCL15 active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% by SDS-PAGE
Form/Format
Lyophilized
Sequence
QELRCLCIQE HSEFIPLKLI KNIMVIFETI YCNRKEVIAV PKNGSM ICLD PDAPWVKATV GPITNRFLPE DLKQKEFPPA MKLLYSVEHE K PLYLSFGRP ENKRIFPFPI RETSRHFADL AHNSDRNFLR DSSEVSL TGS DA
Sequence Length
167
Endotoxin Level
< 0.1 ng per ug of Lungkine
Biological Activity
Determined by its ability to chemoattract human neutrophils using a concentration range of 20.0-100.0 ng/ml.
Related Product Information for CXCL15 active protein
Lungkine is a CXC chemokine that is expressed in lung epithelial cells and, to a lesser extent, in certain fetal tissues. No human homolog has been identified and a specific cell surface receptor has not yet been found. Lungkine expression in lung tissue is elevated in response to inflammation, at which time it acts to specifically recruit neutrophils and direct them into the lung airway. Recombinant murine Lungkine is a 16.3 kDa CXC chemokine consisting of 142 amino acid residues, including four conserved cysteine residues present in CXC chemokines.
Product Categories/Family for CXCL15 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
16.3 kDa
NCBI Official Full Name
C-X-C motif chemokine 15
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 15
NCBI Official Symbol
Cxcl15
NCBI Official Synonym Symbols
Il8; weche; Scyb15; lungkine
NCBI Protein Information
C-X-C motif chemokine 15; interleukin 8; small-inducible cytokine B15; small inducible cytokine subfamily B, member 15
UniProt Protein Name
C-X-C motif chemokine 15
Protein Family
UniProt Gene Name
Cxcl15
UniProt Synonym Gene Names
Scyb15
UniProt Entry Name
CXL15_MOUSE
Uniprot Description
Function: Chemotactic for neutrophils. Involved in lung-specific neutrophil trafficking during normal and inflammatory conditions. Ref.1 Ref.5
Subcellular location: Secreted Ref.1.
Tissue specificity: Expression restricted to the lung, produced by bronchoepithelial cells and is released into the airways. Expressed at low levels in fetal lung. Ref.1 Ref.5
Induction: By inflammation; in lung. Ref.1
Disruption phenotype: Mice develop normally and are fertile. They display normal leukocyte subpopulations in peripheral blood and bone marrow, but the amount of neutrophils is reduced in the airspace. Susceptibility to pneumonia induced by K.pneumoniae is increased with decreased survival and increased bacterial burden in lung. Ref.5
Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
Research Articles on CXCL15
Similar Products
Product Notes
The CXCL15 cxcl15 (Catalog #AAA692121) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse Lungkine (CXCL15) reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: QELRCLCIQE HSEFIPLKLI KNIMVIFETI YCNRKEVIAV PKNGSM ICLD PDAPWVKATV GPITNRFLPE DLKQKEFPPA MKLLYSVEHE K PLYLSFGRP ENKRIFPFPI RETSRHFADL AHNSDRNFLR DSSEVSL TGS DA. It is sometimes possible for the material contained within the vial of "Lungkine (CXCL15), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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