Neuropoietin Active Protein | Ctf2 active protein
Mouse Neuropoietin
Gene Names
Ctf2; NP; Gm494
Reactivity
Mouse
Purity
> 98% by SDS-PAGE
Synonyms
Neuropoietin; Mouse Neuropoietin; Recombinant Murine Neuropoietin; Ctf2 active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% by SDS-PAGE
Form/Format
Lyophilized
Sequence
MAPISPSEPI GQAYSLALYM QKNTSALLQT YLQHQGSPFS DPGFSA PELQ LSTLPSAAVS FKTWHAMEDA ERLSRAQGAF LALTQHLQLV G DDQSYLNPG SPILLAQLGA ARLRAQGLLG NMAAIMTALG LPIPPEE DTL GFVPFGASAF ERKCRGYIVT REYGHWTDRA VRDLALLKAK YS A
Sequence Length
204
Endotoxin Level
< 0.1 ng per ug of Neuropoietin
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.5-0.8 ug/ml.
Related Product Information for Ctf2 active protein
Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex comprising CNTF receptor-a component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human Neuropoietin gene has evolved toward a pseudogene, suggesting that the alternative signaling via CNTF is an effective compensatory pathway. Recombinant murine Neuropoietin is a 19.8 kDa protein containing 183 amino acid residues.
Product Categories/Family for Ctf2 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
19.8 kDa
NCBI Official Full Name
cardiotrophin-2
NCBI Official Synonym Full Names
cardiotrophin 2
NCBI Official Symbol
Ctf2
NCBI Official Synonym Symbols
NP; Gm494
NCBI Protein Information
cardiotrophin-2; CT-2; neuropoietin
UniProt Protein Name
Cardiotrophin-2
Protein Family
UniProt Gene Name
Ctf2
UniProt Synonym Gene Names
Gm494; CT-2; Np
UniProt Entry Name
CTF2_MOUSE
Uniprot Description
Function: Increases the platelet count associated with splenomegaly. May have an important role in neuronal precursor development and maturation.
Subunit structure: Binds to tripartite CNTF receptor complex consisting of CNTF alpha chain, LIFR and IL6ST (in vitro).
Subcellular location: Secreted
By similarity.
Tissue specificity: Not detected in adult tissues.
Developmental stage: Expressed in embryonic life, with a dramatic peak at day 11 of gestation. E10, it is prominently expressed in cells scattered throughout all neuroepithelia, it is also detectable in cranial and dorsal root sensory ganglia, and spinal cord. At E14, outside the nervous system, it is detectable in vibrissae, dermis, and to a lesser extent in skeletal muscle, lung, and kidney.
Sequence similarities: Belongs to the IL-6 superfamily.
Research Articles on Ctf2
Similar Products
Product Notes
The Ctf2 ctf2 (Catalog #AAA692093) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse Neuropoietin reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MAPISPSEPI GQAYSLALYM QKNTSALLQT YLQHQGSPFS DPGFSA PELQ LSTLPSAAVS FKTWHAMEDA ERLSRAQGAF LALTQHLQLV G DDQSYLNPG SPILLAQLGA ARLRAQGLLG NMAAIMTALG LPIPPEE DTL GFVPFGASAF ERKCRGYIVT REYGHWTDRA VRDLALLKAK YS A. It is sometimes possible for the material contained within the vial of "Neuropoietin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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