IL-16 (121 aa) Active Protein | IL-16 active protein
Human IL-16 (121 aa)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Uniprot Description
Function: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Ref.16 Ref.17Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Ref.16 Ref.17Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. Ref.16 Ref.17
Subunit structure: Homotetramer
Probable. According to Ref.19, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C
By similarity. Isoform 3 interacts with HTLV-1 tax. Ref.1 Ref.9 Ref.15 Ref.17
Subcellular location: Interleukin-16: Secreted Ref.12 Ref.15 Ref.16 Ref.17. Isoform 1: Cytoplasm
By similarity Ref.12 Ref.15 Ref.16 Ref.17. Isoform 3: Cytoplasm. Nucleus Ref.12 Ref.15 Ref.16 Ref.17.
Tissue specificity: Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation.
Induction: Isoform 3 is down-regulated in T-cells after TCR activation. Ref.13
Post-translational modification: Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16. Ref.11
Sequence similarities: Contains 4 PDZ (DHR) domains.
Research Articles on IL-16
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Product Notes
The IL-16 il16 (Catalog #AAA691956) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IL-16 (121 aa) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHG DKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW N IIKALPDGP VTIVIRRKSL QSKETTAAGD S. It is sometimes possible for the material contained within the vial of "IL-16 (121 aa), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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