Oncostatin M (227aa) (OSM) Active Protein | OSM active protein

Human Oncostatin M (227aa) (OSM)

Cat. Num. AAA691919

• Reactivity: Human
• Purity: 98 % (SDS-PAGE, HPLC)
• Synonyms: Oncostatin M (227aa) (OSM); Human Oncostatin M (227aa) (OSM); Recombinant Human Oncostatin M; OSM active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: 98 % (SDS-PAGE, HPLC)
• Form/Format: Lyophilized
• Sequence: AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLR EHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ R LPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDT AEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GR VFSKWGES PNRSRRHSPH QALRKGVRRT RPSRKGKRLM TRGQLPR
• Sequence Length: 252

• Endotoxin Level: < 0.1 ng per ug of Oncostatin M
• Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <= 2 ng/ml, corresponding to a specific activity of >= 5 x 105 units/mg.

Related Product Information for OSM active protein

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi\'s sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi\'s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant human Oncostatin M is a 25.7 kDa protein, containing 227 amino acid residues.

Product Categories/Family for OSM active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 10092621
• NCBI GeneID: 5008
• NCBI Accession #: NP_065391.1
• NCBI GenBank Nucleotide #: NM_020530.4
• UniProt Accession #: P13725; Q6FHP8; Q9UCP6
• Molecular Weight: 26.0 kDa
• NCBI Official Full Name: oncostatin-M preproprotein
• NCBI Official Synonym Full Names: oncostatin M
• NCBI Official Symbol: OSM
• NCBI Protein Information: oncostatin-M
• UniProt Protein Name: Oncostatin-M
• Protein Family: Oncostatin
• UniProt Gene Name: OSM
• UniProt Synonym Gene Names: OSM
• UniProt Entry Name: ONCM_HUMAN

NCBI Description

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration

By similarity. Ref.8 Ref.12

Subcellular location: Secreted.

Post-translational modification: Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.

Sequence similarities: Belongs to the LIF/OSM family.