PF-4 (CXCL4) active protein
Mouse PF-4 (CXCL4)
Gene Names
Pf4; Cxcl4; Scyb4
Reactivity
Mouse
Purity
> 75% by SDS-PAGE and HPLC analysis
Synonyms
PF-4 (CXCL4); Mouse PF-4 (CXCL4); Recombinant Mouse Wnt-3a; PF-4 (CXCL4) active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 75% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized
Sequence
VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQ LIAT LKNGRKICLD RQAPLYKKVI KKILES
Sequence Length
105
Endotoxin Level
< 0.1 ng per ug of Wnt-3a
Biological Activity
Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml.
Related Product Information for PF-4 (CXCL4) active protein
PF4 or CXCL4 is a member of the CXC chemokine family. Mouse CXCL4 is a 105 amino acid (aa) protein with a 29 aa signal sequence and a 76 aa mature protein. CXCL4 has homology with IL8 and beta-thromboglobulin. Mouse and human CXCL4 share a 64% identity. Mouse and rat CXCL4 share 89% identity. CXCL4 contains several heparin-binding sites at the C-terminal region. The active protein consists of a tetramer composed of individual CXCL4 subunits. Megakaryocytes synthesize CXCL4 and store it as tetramers in alpha-granules. The CXCL4 tetramers are secreted by activated platelets and can be measured at micromolar levels in serum. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes. CXCL4 does not contain an ELR motif. However, many other fuctions have been observed for CXCL4. CXCL4 is involved in monocyte survivial and differentiation into macrophages, and it has antiangiogenic activity. CXCL4 has been demonstrated to inhibit the binding of FGF2 to high-affinity receptors and its subsequent internalization. Cell surface neutrophil chondroitin sulfate chains serve as CXCL4 binding sites; affinity is controlled by the degree of sulfation of these chains.
Product Categories/Family for PF-4 (CXCL4) active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
38-41 kDa
NCBI Official Full Name
platelet factor 4
NCBI Official Synonym Full Names
platelet factor 4
NCBI Official Symbol
Pf4
NCBI Official Synonym Symbols
Cxcl4; Scyb4
NCBI Protein Information
platelet factor 4; PF-4; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4
UniProt Protein Name
Platelet factor 4
UniProt Gene Name
Pf4
UniProt Synonym Gene Names
Cxcl4; Scyb4; PF-4
UniProt Entry Name
PLF4_MOUSE
Uniprot Description
Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation
By similarity.
Subunit structure: Homotetramer
By similarity.
Subcellular location: Secreted.
Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
Research Articles on PF-4 (CXCL4)
Similar Products
Product Notes
The PF-4 (CXCL4) pf4 (Catalog #AAA691831) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse PF-4 (CXCL4) reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQ LIAT LKNGRKICLD RQAPLYKKVI KKILES. It is sometimes possible for the material contained within the vial of "PF-4 (CXCL4), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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