Lymphotactin Active Protein | XCL1 active protein

Human Lymphotactin

Cat. Num. AAA691682

• Gene Names: XCL1; LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
• Reactivity: Human
• Purity: 98 % (SDS-PAGE, HPLC)
• Synonyms: Lymphotactin; Human Lymphotactin; Recombinant Human Lymphotactin; XCL1 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: 98 % (SDS-PAGE, HPLC)
• Form/Format: Lyophilized
• Sequence: GSEVSDKRTC VSLTTQRLPV SRIKTYTITE GSLRAVIFIT KRGLKV CADP QATWVRDVVR SMDRKSNTRN NMIQTKPTGT QQSTNTAVTL T G
• Sequence Length: 114

• Endotoxin Level: < 0.1 ng per ug of Lymphotactin
• Biological Activity: Determined by its ability to chemoattract human T cells using a concentration of 10.0-100.0 ng/ml.

Related Product Information for XCL1 active protein

Lymphotactin is the only known member of the C-chemokine family and signals through the receptor XCR1, formally known as GPR5. The spleen shows the highest level of lymphotactin compared to peripheral leukocytes, lung, colon and small intestine. Lymphotactin is chemotactic towards lymphocytes but not towards monocytes or neutrophils. Recombinant human Lymphotactin is a 10.0 kDa protein consisting of 92 amino acid residues.

Product Categories/Family for XCL1 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4506853
• NCBI GeneID: 6375
• NCBI Accession #: NP_002986.1
• NCBI GenBank Nucleotide #: NM_002995.2
• UniProt Accession #: P47992; Q52MA8
• Molecular Weight: 10 kDa
• NCBI Official Full Name: lymphotactin
• NCBI Official Synonym Full Names: chemokine (C motif) ligand 1
• NCBI Official Symbol: XCL1
• NCBI Official Synonym Symbols: LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
• NCBI Protein Information: lymphotactin; SCM-1-alpha; lymphotaxin; cytokine SCM-1; c motif chemokine 1; XC chemokine ligand 1; single cysteine motif 1a; small-inducible cytokine C1; small inducible cytokine subfamily C, member 1 (lymphotactin)
• UniProt Protein Name: Lymphotactin
• Protein Family: Lymphotactin
• UniProt Gene Name: XCL1
• UniProt Synonym Gene Names: LTN; SCYC1
• UniProt Entry Name: XCL1_HUMAN

NCBI Description

This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Nov 2010]

Uniprot Description

Function: Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

Subcellular location: Secreted.

Tissue specificity: Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.

Sequence similarities: Belongs to the intercrine gamma family.