MDC (67 aa) Active Protein | MDC active protein
Human MDC (67 aa)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.
Subunit structure: Can bind to LGI1 and LGI4
By similarity.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Expressed predominantly in brain. Slightly detected or not at all in other tissues.
Domain: A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.
Post-translational modification: The precursor is cleaved by a furin endopeptidase
By similarity.
Sequence similarities: Contains 1 disintegrin domain.Contains 1 EGF-like domain.Contains 1 peptidase M12B domain.
Research Articles on MDC
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Product Notes
The MDC adam11 (Catalog #AAA691472) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human MDC (67 aa) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRD KEIC ADPRVPWVKM ILNKLSQ. It is sometimes possible for the material contained within the vial of "MDC (67 aa), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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