Mouse anti-Human Resistin Monoclonal Antibody | anti-RETN antibody

Mouse Anti-Human Resistin

Cat. Num. AAA690775

• Gene Names: RETN; ADSF; RSTN; XCP1; FIZZ3; RETN1
• Reactivity: Human
• Purity: Protein A chromatography
• Synonyms: Resistin; Monoclonal Antibody; Mouse Anti-Human Resistin; Anti-human Resistin; anti-RETN antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2
• Specificity: To detect human Resistin by Western Blot analysis this antibody can be used at a concentration of 0.20-0.40 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant human Resistin is 0.20-0.40 ng/lane, under non-reducing conditions.
• Purity/Purification: Protein A chromatography
• Form/Format: Lyophilized
• Sequence Length: 108

• Application Notes: In a sandwich ELISA (assuming 100ul/well), a concentration of 4.0-8.0 ug/ml of this antibody will detect at least 200 pg/ml of recombinant human Resistin when used in conjunction with compatible secondary reagents.
• Antibody Generation: Produced in BALB/c mice using highly pure (>98%) recombinant human Resistin as the immunizing antigen. This IgG2bK antibody was purified from ascites fluid by Protein A affinity chromatography.
• Buffer: PBS, pH 7.2

Related Product Information for anti-RETN antibody

Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-alpha and RELM-beta share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin\'s ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis. Recombinant human Resistin is a 19.5 kDa disulfide-linked homodimeric protein composed of two identical 92 amino acid chains linked by a single disulfide bond.

NCBI and Uniprot Product Information

• NCBI GI #: 301129180
• NCBI GeneID: 56729
• NCBI Accession #: NP_001180303.1
• NCBI GenBank Nucleotide #: NM_001193374.1
• UniProt Accession #: Q9HD89; Q540D9; D6W649
• Molecular Weight: 11,419 Da
• NCBI Official Full Name: resistin
• NCBI Official Synonym Full Names: resistin
• NCBI Official Symbol: RETN
• NCBI Official Synonym Symbols: ADSF; RSTN; XCP1; FIZZ3; RETN1
• NCBI Protein Information: resistin; resistin delta2; found in inflammatory zone 3; cysteine-rich secreted protein FIZZ3; adipose tissue-specific secretory factor; cysteine-rich secreted protein A12-alpha-like 2; c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1
• UniProt Protein Name: Resistin
• Protein Family: Resistin
• UniProt Gene Name: RETN
• UniProt Synonym Gene Names: FIZZ3; HXCP1; RSTN; ADSF
• UniProt Entry Name: RETN_HUMAN

NCBI Description

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

Subunit structure: Homodimer; disulfide-linked

By similarity.

Subcellular location: Secreted.

Tissue specificity: Expressed only in fatty tissues.

Sequence similarities: Belongs to the resistin/FIZZ family.