Testing Data
(Fig-1: Expression analysis of MUM1. Anti-MUM1 antibody (11-7551) was used at 1 ug/ml on (1) Jurkat and (2) Ramos lysates.)
Rabbit anti-Human MUM1 Polyclonal Antibody | anti-MUM1 antibody
Polyclonal Antibody to MUM1
Gene Names
MUM1; MUM-1; EXPAND1; HSPC211
Reactivity
Human
Applications
Western Blot
Purity
PurifiedProtein A Chromatography
Synonyms
MUM1; Polyclonal Antibody; Polyclonal Antibody to MUM1; EXPAND1; Mutated melanoma-associated antigen 1; Protein expandere; Antibody to MUM1; Anti-MUM1 Antibody; MUM1 Antibody; anti-MUM1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified
Protein A Chromatography
Protein A Chromatography
Form/Format
25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Sequence Length
710
Applicable Applications for anti-MUM1 antibody
Western Blot (WB)
Application Notes
WB: 1-2 ug/ml
Immunogen Information
A partial length recombinant MUM1 protein (amino acids 52-278) was used as the immunogen for this antibody.
Antigen
MUM1
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Testing Data
(Fig-1: Expression analysis of MUM1. Anti-MUM1 antibody (11-7551) was used at 1 ug/ml on (1) Jurkat and (2) Ramos lysates.)
Testing Data
(Fig-1: Expression analysis of MUM1. Anti-MUM1 antibody (11-7551) was used at 1 ug/ml on (1) Jurkat and (2) Ramos lysates.)
Related Product Information for anti-MUM1 antibody
MUM1 is a member of the interferon regulatory factor family of transcription factors. This protein is required at several stages of B-cell development, including in the differentiation of mature B cell into antibody-secreting plasma cells, and is also critical for Th2 and Th17 T-cell differentiation and T-cell cytotoxic function. MUM1 is normally expressed in plasma cells, melanocytes, some B cells, and activated T cells. MUM1 acts as an architectural component of the chromatin, which in response to DNA damage serves as an accessory factor to promote cell survival. Depletion of MUM1 or inactivation of its PWWP domain resulted in chromatin compaction. Upon DNA damage, MUM1 rapidly concentrates at the vicinity of DNA damage sites via its direct interaction with 53BP1. Ablation of this interaction impaired damage-induced chromatin decondensation, which is accompanied by sustained DNA damage and hypersensitivity to genotoxic stress. MUM1 acts as a helpful marker in the differential identification of AITL(Angioimmunoblastic T cell Lymphoma with HRS-like cells and cHL.
Product Categories/Family for anti-MUM1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
80,700 Da
NCBI Official Full Name
PWWP domain-containing protein MUM1
NCBI Official Synonym Full Names
melanoma associated antigen (mutated) 1
NCBI Official Symbol
MUM1
NCBI Official Synonym Symbols
MUM-1; EXPAND1; HSPC211
NCBI Protein Information
PWWP domain-containing protein MUM1
UniProt Protein Name
PWWP domain-containing protein MUM1
Protein Family
UniProt Gene Name
MUM1
UniProt Synonym Gene Names
EXPAND1; MUM-1
Uniprot Description
MUM1: Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. Belongs to the MUM1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; nucleus
Molecular Function: nucleosome binding; protein binding
Biological Process: DNA repair; establishment and/or maintenance of chromatin architecture
Research Articles on MUM1
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Product Notes
The MUM1 mum1 (Catalog #AAA668718) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to MUM1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MUM1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1-2 ug/ml. Researchers should empirically determine the suitability of the MUM1 mum1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MUM1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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