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Western Blot (WB) (Expression analysis of TXNIP/VDUP1 . Anti-TXNIP/VDUP1 antibody (11-3023) was used at 1 µg/ml on Y79 lysate)

Rabbit anti-Human TxNIP/VDUP1 Polyclonal Antibody | anti-TxNIP/VDUP1 antibody

TxNIP/VDUP1 Polyclonal Antibody

Gene Names
TXNIP; THIF; VDUP1; HHCPA78; EST01027
Reactivity
Human
Applications
Western Blot
Synonyms
TxNIP/VDUP1; Polyclonal Antibody; TxNIP/VDUP1 Polyclonal Antibody; anti-TxNIP/VDUP1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Form/Format
Purified (Liquid)
Concentration
0.5mg/ml, 200µl (varies by lot)
Sequence Length
391
Applicable Applications for anti-TxNIP/VDUP1 antibody
Western Blot (WB)
Application Notes
Western Blot: 1-3 µg/ml
Antigen
TxNIP/VDUP1
Immunogen
A partial recombinant TxNIP protein (amino acids 50-300) was used as the immunogen for this antibody.
Preparation and Storage
Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.

Western Blot (WB)

(Expression analysis of TXNIP/VDUP1 . Anti-TXNIP/VDUP1 antibody (11-3023) was used at 1 µg/ml on Y79 lysate)

Western Blot (WB) (Expression analysis of TXNIP/VDUP1 . Anti-TXNIP/VDUP1 antibody (11-3023) was used at 1 µg/ml on Y79 lysate)
Product Categories/Family for anti-TxNIP/VDUP1 antibody
TLR

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
37,319 Da
NCBI Official Full Name
thioredoxin-interacting protein
NCBI Official Synonym Full Names
thioredoxin interacting protein
NCBI Official Symbol
TXNIP
NCBI Official Synonym Symbols
THIF; VDUP1; HHCPA78; EST01027
NCBI Protein Information
thioredoxin-interacting protein; thioredoxin binding protein 2; thioredoxin-binding protein 2; upregulated by 1,25-dihydroxyvitamin D-3; vitamin D3 up-regulated protein 1
UniProt Protein Name
Thioredoxin-interacting protein
UniProt Gene Name
TXNIP
UniProt Synonym Gene Names
VDUP1
UniProt Entry Name
TXNIP_HUMAN

Uniprot Description

TXNIP: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Belongs to the arrestin family.

Protein type: Mitochondrial; Apoptosis; Motility/polarity/chemotaxis; Tumor suppressor

Chromosomal Location of Human Ortholog: 1q21.1

Cellular Component: cytoplasm; mitochondrial intermembrane space; cytosol; nucleus

Molecular Function: enzyme inhibitor activity; protein binding; ubiquitin protein ligase binding

Biological Process: response to drug; transcription, DNA-dependent; positive regulation of apoptosis; platelet-derived growth factor receptor signaling pathway; negative regulation of cell division; negative regulation of transcription from RNA polymerase II promoter; cell cycle; response to estradiol stimulus; regulation of cell proliferation; keratinocyte differentiation; response to hydrogen peroxide; response to mechanical stimulus; protein import into nucleus; negative regulation of catalytic activity; response to glucose stimulus; innate immune response; response to calcium ion; response to progesterone stimulus

Research Articles on TxNIP/VDUP1

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Product Notes

The TxNIP/VDUP1 txnip (Catalog #AAA668087) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TxNIP/VDUP1 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TxNIP/VDUP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1-3 µg/ml. Researchers should empirically determine the suitability of the TxNIP/VDUP1 txnip for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TxNIP/VDUP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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