SARM Peptide | SARM1 peptide

SARM (SAM and ARM-containing Protein) (Control Peptide)

Cat. Num. AAA659584

• Gene Names: SARM1; SARM; SAMD2; MyD88-5
• Applications: ELISA, Western Blot
• Purity: Purified; Purified
• Synonyms: SARM; SARM (SAM and ARM-containing Protein) (Control Peptide); SARM1 peptide

• Purity/Purification: Purified; Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.

• Applicable Applications for SARM1 peptide: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in antibody blocking.; Dilution: Western Blot : Incubatte the peptide with equal volume of antibody for 30 min at 37 degree C.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for SARM1 peptide

Control peptide for S0097-70 SARM.

Product Categories/Family for SARM1 peptide

Molecular Biology; MB-Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 154090976
• NCBI GeneID: 23098
• NCBI Accession #: NP_055892.2
• NCBI GenBank Nucleotide #: NM_015077.3
• UniProt Accession #: Q6SZW1; O60277; Q7LGG3; Q9NXY5
• Molecular Weight: 79,388 Da
• NCBI Official Full Name: sterile alpha and TIR motif-containing protein 1
• NCBI Official Synonym Full Names: sterile alpha and TIR motif containing 1
• NCBI Official Symbol: SARM1
• NCBI Official Synonym Symbols: SARM; SAMD2; MyD88-5
• NCBI Protein Information: sterile alpha and TIR motif-containing protein 1; tir-1 homolog; SAM domain-containing protein 2; sterile alpha and Armadillo repeat protein; sterile alpha motif domain-containing protein 2; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
• UniProt Protein Name: Sterile alpha and TIR motif-containing protein 1
• Protein Family: Sterile alpha and TIR motif-containing protein
• UniProt Gene Name: SARM1
• UniProt Synonym Gene Names: KIAA0524; SAMD2; SARM; MyD88-5
• UniProt Entry Name: SARM1_HUMAN

Uniprot Description

Function: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. Ref.4 Ref.5 Ref.6 Ref.9

Subunit structure: Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. Interacts with MAPK10/JNK3 and SDC2 (via cytoplasmic domain)

By similarity. Ref.5

Subcellular location: Cytoplasm. Cell projection › axon

By similarity. Cell projection › dendrite

By similarity. Cell junction › synapse

By similarity. Mitochondrion. Note: Associated with microtubules

By similarity. Ref.9 Ref.10

Tissue specificity: Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta. Ref.1 Ref.7

Induction: Up-regulated by lipopolysaccharides (LPS). Ref.9

Sequence similarities: Contains 2 SAM (sterile alpha motif) domains.Contains 1 TIR domain.

Caution: Was initially (Ref.1) reported to contain ARM repeats. Such repeats are however not predicted by any detection method.