TLR10 peptide

TLR10 (Toll Like Receptor 10) (Control Peptide)

Cat. Num. AAA659574

• Gene Names: TLR10; CD290
• Applications: ELISA, Western Blot
• Purity: Purified; Purified
• Synonyms: TLR10; TLR10 (Toll Like Receptor 10) (Control Peptide); TLR10 peptide

• Purity/Purification: Purified; Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.

• Applicable Applications for TLR10 peptide: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: The peptide is used for blocking the activity of TLR10 (IN) antibody. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37 degree C.
• Location: 14aa from the middle of human TLR10 (1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for TLR10 peptide

Molecular Biology; MB-Toll Like Receptors (TLR)

NCBI and Uniprot Product Information

• NCBI GI #: 67626203
• NCBI GeneID: 81793
• UniProt Accession #: Q9BXR5; Q32MI7; Q32MI8; Q5FWG4; Q6UXL3; A8K7L1; B3Y668; D1CS21; D1CS22
• Molecular Weight: 94,564 Da
• NCBI Official Full Name: TLR10
• NCBI Official Synonym Full Names: toll-like receptor 10
• NCBI Official Symbol: TLR10
• NCBI Official Synonym Symbols: CD290
• NCBI Protein Information: toll-like receptor 10
• UniProt Protein Name: Toll-like receptor 10
• Protein Family: Toll-like receptor
• UniProt Gene Name: TLR10
• UniProt Entry Name: TLR10_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Uniprot Description

Function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

By similarity.

Subunit structure: Binds MYD88 via their respective TIR domains

By similarity. Homodimer

Potential. Ref.8

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Sequence similarities: Belongs to the Toll-like receptor family.Contains 15 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 TIR domain.