Cat Hedgehog Interacting Protein ELISA Kit | HHIP elisa kit
Cat Hedgehog Interacting Protein ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]
Uniprot Description
HHIP: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Belongs to the HHIP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q28-q32
Cellular Component: cell surface; integral to plasma membrane; cytoplasm; extracellular region
Molecular Function: protein binding; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; zinc ion binding; quinone binding
Biological Process: smoothened signaling pathway; dorsal/ventral pattern formation; skeletal morphogenesis; negative regulation of smoothened signaling pathway; carbohydrate metabolic process; neuroblast proliferation; regulation of fibroblast growth factor receptor signaling pathway; negative regulation of signal transduction