Tissue Factor [Cys39] Peptide | F3 peptide
Tissue Factor [Cys39] (33-53)
~95%. Purified by HPLC.
~95%. Purified by HPLC.
Tissue Factor (TF) is expressed in the plasma membranes of many cell types. It is an integral membrane glycoprotein consisting of a single chain molecule of 44kD. TF consists of an extracellular domain (residues 1-219), a transmembrane domain (residues 220-242) and the C-terminal intracellular domain (residues 243-263). Most abundant in the tissue adventitia, TF becomes exposed to blood at the site of vascular injury. The availability of TF is important in initiating coagulation by acting as a receptor for both the zymogen and protease forms of plasma Factor VII (FVII and FVIIa). It also mediates the conversion of bound FVII to FVIIa. The binding of FVII to TF in the presence of a negatively charged surface such as a phospholipid (or cell surface) promotes the auto activation of FVII by FVIIa. The TF-FVIIa complex in the presence of calcium ions proteolytically activates FIX and FX. These enzyme products are then capable of activating FVII to FVIIa by feedback amplification. The activity of TF-.VIIa activity is regulated by a TFPI (Tissue Factor Pathway Inhibitor), a member of the Kunin superfamily of protease inhibitors. TFPI contains three Kunitz domains and is able to bind and inhibit the TF-FVIIa complex in the presence of activated FX and calcium ions. Antithrombin has also been reported to inhibit FVIIa activity in the presence of TF and heparin. Although a membrane protein, low levels of TF products have been demonstrated in plasma.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Description
Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Ref.6
Subunit structure: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. Ref.15
Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein Ref.6. Isoform 2: Secreted Ref.6.
Tissue specificity: Lung, placenta and pancreas. Ref.6
Induction: TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. Ref.14
Sequence similarities: Belongs to the tissue factor family.
Research Articles on F3
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Product Notes
The F3 f3 (Catalog #AAA658512) is a Peptide produced from Synthetic peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tissue Factor [Cys39], Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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