Hamster Kidney and Brain Protein ELISA Kit | KIBRA elisa kit
Hamster Kidney and Brain Protein ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway. Ref.5 Ref.6 Ref.7
Subunit structure: Forms a complex with Mer and Ex. Interacts (via domain WW 1) with Ex (via RXPPXY motif). Interacts with Mer, Sav, Hpo and Wts. Ref.5 Ref.6 Ref.7
Subcellular location: Cytoplasm. Apical cell membrane. Note: Localizes at the apical cortex of epithelial cells and cytoplasmic, punctate. Ref.5 Ref.7
Tissue specificity: Expressed in ovarian posterior follicle cells and wing disks (at protein level). Ref.6
Disruption phenotype: Homozygous embryonic lethality, oogenesis defects, tissue overgrowth characterized by excessive cell proliferation and diminished apoptosis. Ref.5 Ref.6 Ref.7
Sequence similarities: Belongs to the WWC family. KIBRA subfamily.Contains 1 C2 domain.Contains 2 WW domains.
Research Articles on KIBRA
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Product Notes
The Hamster KIBRA kibra (Catalog #AAA065434) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA065434 ELISA Kit recognizes Hamster KIBRA. It is sometimes possible for the material contained within the vial of "Kidney and Brain Protein, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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