Angiotensin Converting Enzyme, Rabbit Enzyme | ACE enzyme
Angiotensin Converting Enzyme, Rabbit (ACE, CD143, Dipeptidyl Carboxypeptidase I, DCP1, Kininase II)
NCBI and Uniprot Product Information
Uniprot Description
Function: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety
By similarity.
Catalytic activity: Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Cofactor: Binds 2 zinc ions per subunit. Isoform Testis-specific only binds 1 zinc ion per subunit
By similarity.Binds 3 chloride ions per subunit
By similarity.
Enzyme regulation: Strongly activated by chloride. Specifically inhibited by lisinopril. Ref.11
Subcellular location: Angiotensin-converting enzyme, soluble form: Secreted
By similarity. Cell membrane; Single-pass type I membrane protein
By similarity.
Tissue specificity: Testis-specific isoform is expressed in spermatocytes, adult testis.
Post-translational modification: N-glycosylated. Ref.7Phosphorylated by CK2 on Ser-1303; which allows membrane retention
By similarity.
Sequence similarities: Belongs to the peptidase M2 family.
Biophysicochemical propertiesKinetic parameters:KM=0.6 mM for Hip-His-Leu Ref.11KM=0.09 mM for angiotensin I
Research Articles on ACE
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Product Notes
The ACE ace (Catalog #AAA653782) is an Enzyme produced from Rabbit lung and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Angiotensin Converting Enzyme, Rabbit can be used in a range of immunoassay formats including, but not limited to, Functional Assay. Suitable for use in Functional Assays. Researchers should empirically determine the suitability of the ACE ace for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Angiotensin Converting Enzyme, Rabbit, Enzyme" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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